Simple Reverse Genetics Approach to Elucidating the Biosynthetic Pathway of Complex Thiopeptide Nocathiacin
نویسندگان
چکیده
Dr. M. C. Wei, Dr. J. Deng, K. Feng, Dr. S. Z. Wang, Dr. N. Liu, Prof. Dr. Y. J. Chen Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009, People’s Republic of China Tel: 86-25-83271045, Fax: 86-25-83271249 Email: [email protected] Prof. Dr. Y. J. Chen Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA
منابع مشابه
Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.
Characterization of the biosynthetic gene cluster of glycosylated antibiotic nocathiacin I (NOC-I) here adds new insights to thiopeptide biosynthesis, showing the NOC-specific tailoring and unusual sugar formation. NOC-I biosynthesis shares the paradigm for forming a common thiopeptide core and the generality for converting to an e series member, as that of the parent compound nosiheptide (NOS)...
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